#3 / 2017

Serumal concentrations of the main pro-inflammatory mediators of “the first wave” of IL-17A, IL-1β, TNF-a and antiinflammatory IL-4, determined by sandwich-type enzyme immunoassay at patients with a coronary atherosclerosis with the outcome in an ischemic heart disease (n=10) did not differ from donors (n=12; P>0,05) and did not exceed the lower limits of method sensitivity (0–20 pg/ml). The most informative data confirming participation of IL-17A, IL-1β, TNF-a in development of the ischemic heart disease have been obtained at cultivation of intact and stimulated peripheral blood mononuclear cells (PBMC) and neutrocytes in standard medium. Levels of spontaneous production of IL-17A, IL-1β, TNF-a of PBMC in ischemic heart disease patients considerably exceeded similar indicators at donors: IL-17A (correspondingly 65,85±15,89 pg/ml and 7,95±5,24 pg/ml; t=3.46, P<0,01); IL-1β (65±22,19 pg/ml and 10,88±3,86 pg/ml; t=2,40; P<0,01) TNF-α (435,63±77,14 pg/ml and 31,56±13,71 pg/ml; t=5,16; P <0,01). At sti-mulation in vitro PHA of PBMC of patients produced statistically significantly higher concentrations of IL-1β (corre-spondingly 91,46±17,55 pg/ml and 24,27±6,85 pg/ml; t=3,57; P<0,01), TNF-a (672,22±30.69 pg/ml and 406,41±46,38 pg/ml; t=4,78; P<0,01). The hyperproduction of IL-17A, IL-1β, TNF-a is noted also for intact and stimu-lated in vitro PHA of neutrophils of patients.

34-41.pdf

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The main objective of the study is to perform a comparative analysis of the major parameters of the functional vigor levels among female athletes specializing in all-round track-and-field athletics. In the furtherance of this goal, investigations have been carried out involving two groups of female athletes specializing in all-round track-and-field athletics. The first group consisted of athletes of Category 1 and Candidate Masters of Sports (n=18), the second group consisted of Masters of Sports and Masters of Sports of International Grade (n=7). It has been established that highly qualified female athletes have substantial advantage in physical vigor and physical endurance, aerobic and anaerobic performance. Well-trained female athletes have the better indices of lability and mobility of nervous processes and lower level of state anxiety. All-round female athletes of Category 1 and Candidate Master of Sports have shown the low degree of regulatory mechanisms tension and relatively low level of regulatory effects on human organism as a whole, which reflects the relatively high level of functional capacities of physiological systems taken separately. Highly qualified female athletes have shown a relatively high level of regulatory mechanisms tension and the great strength of regulatory effects on physiological systems, which is an evidence of higher level of functional optimization increasing the capacity of human organism as a whole.

42-50.pdf

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Ratios of IL-17A, IL-1β; TNF-α;and IL-4 in serumal samples, supernatants of intact and stimulated in vitro PHA of peripheral blood mononuclear cells at patients with an ischemic stroke (n=10) and unrelated donors without clinical implications and heriditary burdeness of cardiovascular diseases (n=12) authentically differ (Р<0,05) in three cytokines: IL-17A, IL-1β, and TNF-α. At patients with an ischemic stroke, unlike donors, serumal concentrations of IL-17A, levels of spontaneous and stimulated PHA of production IL-1; TNF-α are statistically significantly (P≤0,05) increased. The contents of IL-4 in the studied biological media do not exceed 0,25 pg/ml and have no reliable dif-ferences for all examined groups (Р>0,05).

51-57.pdf

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Data on fauna of water mites (Hydrachnidia) in Terek headwaters are provided (within Kabardino-Balkarian Republic). Eight water mite species have been found in water basins of Kabardino-Balkaria – Eylais hamata Koenike, Eylais meridionalis Thor, Hydrachna geographica Muller, Lebertia dubia Thor, Mixobates uncatus (Sokolow), Atractides ovalis Koenike, Piona longipalpis Krendowsky and Mideopsis orbicularis (Muller). All of them, except Hy-drachna geographica, are described for the first time for fauna of Kabardino-Balkarian Republic.

58-62.pdf

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Spontaneous and stimulated NK activity of peripheral blood mononuclear cells (PBMC) in donors and patients with the ischemic stroke which developed against the background of a cerebrovascular atherosclerosis is investigated on NK-sensitive cells of K-562 erythromyeloblastic leukosis at ratios of KM and effectors 1:1; 1:5 and 1:10. Cytotoxic activity of PBMC at patients with an ischemic stroke is reliably lower than at donors (P≤0,05) at all studied ratios.

63-68.pdf

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The paper presents the results of many-year researches on ecological test of sunflower varieties focused on assessment and selection for farms of the most high-yielding and high-oil-bearing hybrids with high resistance to diseases. The most promising sunflower hybrids providing 136–183% of production profitability of oilseeds of the studied hybrids are established.

69-74.pdf

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The spontaneous and induced by a phytohemagglutinin NK activity of mononuclear cells (PBMC) and neutrocytes released from peripheral blood of sick people with coronary heart disease (n=19) is reliably (P≤0,01) lower than that of donors (n=15) which demonstrates suppression of a cellular link of immune system. At 1:1 (a); 1:5(b); 1:10 (c) ratios of cell targets (K-K562) and effectors (Kef) the NK activity of intact PBMC is at patients and donors, respec-tively: a) 31,06±2,99 and 41,60±2,68% (Р<0,05); b) 36,41±3,04 and 57,3±5,87% (Р<0,01); c) 29,61±4,77 and 55,57±5,26% (Р<0,01). Cytotoxicity of intact neutrocytes at patients and donors at the same ratios of Km/Kef makes: a) 15,44±3,22 and 36,15±5,62% (Р<0,001); b) 17,76±1,25 and 33,63±1,08% (Р<0,05); c) 8,13±2,0 and 24,25±4,33% (Р<0,001). PHA in vitro increases the NK activity of neutrocytes of patients and donors, correspondinly: a) 27,22±3,66 and 41,55±4,58% (Р<0,05); b) 33,21±3,7 and 56,98±5,33% (Р<0,01); c) 28,56±3,17 and 55,62±6,43% (P<0,01).

75-81.pdf

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The paper is devoted to the analysis of demographic, social and ecological features of the Republic of Adyghea. The authors examine the principles and methods of the description and mapping the spatial and temporary aspects of interaction of the person and the environment. Examples of the maps recommended for the section “Population and Settlements” of the regional geographic-ecological atlas are given.

82-87.pdf

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The results of studying the restoration potential of Taxus baccata in the central part of the Western Caucasus are presented. The places and conditions of the growth of the species in the studied region are determined. A generally low level of renewal of the species is noted. The results of a twelve-year monitoring of the state of undergrowth in different types of forests are presented. The great success of renewal in beech communities is noted.

88-94.pdf

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Mathematics

The aim of this article is to study the Cauchy problem solutions behavior for neutral differential equations with rapidly oscillating right-hand side. It has been established that the result of the classical averaging principle of N.N. Bogolyubov-N.M. Krylov is not true for the Cauchy problem solutions. A counterexample is constructed in which the non-averaged equation solutions do not converge to the solution of the corresponding problem for the averaged equation. The compactness of the non-averaged problem solution set is proved. New formulations of the averaging principle for neutral type equations with rapidly oscillating right-hand side are given.

13-26.pdf

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This paper examines for the first time the problems related to the characteristic polynom determination and spectra calculation of pre-fractal graphs with alternating star-primings, cycle-primings and chain-primings saving out contiguity of old edges in trajectory. The theorems representing spectra calculation algorithms of the considered graphs are proved.

27-33.pdf

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Technical Sciences

The general mathematical model is constructed for the knapsack schemes of information security, special cases of which are the known schemes of additive and multiplicative knapsacks. In terms of this general model some basic algorithms of information encryption and decryption are formulated.

95-99.pdf

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The paper explores an approach to the accounting for initial information uncertainty in system researches. It consists in the inclusion of uncertainty as one of the parameters in the studied mathematiocal model of thesystem. This approach makes it possible to consider a large number of alternatives and take into account the different possible solutions to the problem. In this regard, we consider the existing classification of the concept of “uncertainty”. The mathematical apparatus for recording and eliminating uncertainty is described. The practical application of the proposed approach, taking into account the initial information uncertainty in the implementation stage of forecasting as part of system research is realized. The prediction process is regarded as an iterative procedure to reduce uncertainty in the management of decision-making as part of the situational center.

100-108.pdf

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The paper provides analysis of requirements to the 70V oil, methods and oil quality control equipment. The modern instruments for quality control of transformer oil are presented. The diagnostic capabilities of these devices are analyzed not only for transformer oil, but also for operated electrical equipment.

109-121.pdf

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An algorithm for finding an acceptable schedule for an operational scheduling task with precedence relations set on a set of operations is proposed. The algorithm is based on the application of the enterprise object model. The analysis of the management of the obtained schedule is carried out. The structure of the information system of operational-calendar planning is considered. The example of the process of adding a new order to the schedule reveals the relationship of industrial information systems of different levels.

122-127.pdf

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The paper examines the issues related to the functionality of modern DLP-systems, domestic DLP-systems, and the relationship of the commissioning of the DLP-system with the solution of organizational and legal issues. The publication provides recommendations for changes in local regulations. An algorithm for implementing the DLP-system in the organization is proposed.

128-133.pdf

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Use of special trailers makes it possible to improve performance and to increase the number of allowable types of transported goods. Trailer vehicles can be with self-loading body, with hopper, and also with a side (or both sides) unloading. However, existing car trailers and semitrailers for the transportation and unloading of bulk cargoes have a number of significant disadvantages that do not permit their use in certain driving situations. In particular, their application is limited to traditional methods of unloading. The longitudinal and lateral stability of existing trailers and semi-trailers is restricted. Also unloading of existing trailers and semi-trailers on objects of low height and width is hampered, for example in tunnels. The above mentioned shortcomings can be eliminated by the development of a new vehicle with the non-traditional way of unloading.

134-138.pdf

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The paper discusses the main modern promising methods of behavioral biometry used for information security for users authentication. Their advantages and risks of application are analyzed.

139-142.pdf

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The main task in the analysis of time series is the reconstruction of the dynamical system that generated this series. The problem of constructing a model of a dynamical system from a one-dimensional time series can be solved by data assimilation methods: variational or by Kalman filtering. The work of each step of the Kalman filter can be divided into two stages: forecast and correction. The forecast phase calculates the state vector of the system by its value in the previous step of the filter operation. At the stage of correction, the algorithm receives data from current measurements (observations), which are used to refine the predicted value of the state vector, and calculate the actual estimate of the state vector of the dynamic system. The algorithm sequentially processes newly arriving measurement vectors, taking into account the values calculated on the previous cycle. In the next step, the initial conditions are refined by means of the measurements being processed on this cycle. For this, the algorithm calculates the weight of corrections to them based on the covariance matrices of the state and measurement estimates. The initial conditions thus corrected are the output of the Kalman filter on each cycle.

143-148.pdf

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